Endocrine Abstracts

Introduction: Severe hypoglycemia induced by sulfonylurea overdose is a result of insulin hypersecretion. Pasireotide (SOM230) is a multireceptor-targeted somatostatin analogue with high affinity for somatostatin receptor subtypes sstr1,2,3 and especially sstr5, which are expressed on rat and human β cells; pasireotide has been shown to inhibit insulin secretion in both species. The aim of these studies was to investigate the ef...

Somatostatin (somatotrophin release inhibiting factor; SRIF) is produced primarily in the hypothalamus and pancreas and inhibits the secretion of many hormones and neurotransmitters. Moreover, SRIF and SRIF analogs are able to inhibit tumor growth. Many human neuroendocrine and non-neuroendocrine tumors express the five known somatostatin receptors (sst1–5) in different amounts.Tachyphylaxis after prolonged treatment with octreotide (Sand...